Endocrine Abstracts

Congenital hypogonadotropic hypogonadism is characterized by delayed or absent puberty and infertility due to abnormally low levels of gonadotropic hormones and sex steroids. The most common reason for its development is Kallmann syndrome - a rare congenital disorder resulting from impaired migration of GnRH-secreting neurons from the olfactory epithelium to the hypothalamus. It is associated with hyposmia and anosmia. In 1942 Klinefelter described 9 men with gynecomastia, spa...

Introduction: The aim of the study was to assess the function and immunogenicity of thyroid gland of patients undergoing chronic treatment with the opiate agonist Methadone.Material and methods: Cross-sectional, observational study included patients from 18 to 40 years of age undergoing chronic treatment with Methadone for at least 6 months. A total of 176 participants took part in the study. 140 patients were from five clinical programs in Bulgaria and ...